Sleep studies in Finland have identified a rise in inflammatory markers and gene expression from blood samples. 2 groups of young men were compared , one group underwent sleep deprivation by having around 4 hours of sleep per night for a week the second group had 8 hours. Many genes and gene pathways that were related to immune function had their expression increased. Also there was an increase in B Cells (B cells produce antigens that contribute to the bodys defensive reactions), they are also involved in allergic reactions and asthma. (it is known that sleep deprivation correlates with increased asthma symptoms).
There was a rise in molecules providing signals which promote inflammation, and also a rise in the associated receptors (especially TLR4) , in addition C Reactive Protein level was also elevated , both indicating inflammation.
They also looked at the effects of long term sleep, participants were asked to complete questionairres about their health and sleep habits. Groups were compared those who thought they were getting enough sleep with those who thought they werent getting enough sleep.
Again gene – level changes were observed , indications are that shorter sleep correlates with the development of inflammatory diseases such as cardiovascular disease and diabetes. These results had already been shown in eidemilogical studies
THE LEAST YOU NEED TO KNOW
lACK OF SLEEP INCREASES INFLAMMATORY MARKERS IN A SMALL STUDY COMPARING TWO GROUPS IE THOSE GETTING ENOUGH SLEEP AND THOSE NOT GETTING ENOUGH SLEEP . THE RESULTS POINT TO A POTENTIAL FOR INFLAMMATORY DISEASES.